deMEM: a novel divide-and-conquer framework based on de Bruijn graph for scalable multiple sequence alignment
DeMEM enables existing methods like MAFFT to align an extremely large number of sequences, including long sequences that cannot be directly aligned, such as those in a dataset of a thousand monkeypox virus genomes. The deMEM package is free and available at https://github.com/malabz/deMEM.
Authors
- Pinglu Zhang (ORCID: https://orcid.org/0009-0002-1788-3084)
- Zhaoyang Huang (ORCID: https://orcid.org/0000-0002-9839-7020)
- Yan Li (ORCID: https://orcid.org/0000-0002-4445-2135)
- Liang Yu (ORCID: https://orcid.org/0009-0004-5452-2493)
- Yanru Wang (ORCID: https://orcid.org/0000-0001-8272-2450)
- Quan Zou
- Yanming Wei
Institutions
- Xidian University (CN)
- University of Electronic Science and Technology of China (CN)
- Xi'an Polytechnic University (CN)
- Quzhou University (CN)
Publication Details
- Journal
- GigaScience
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1093/gigascience/giaf163
- Citations
- 1
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 22.24