A Case of Pathological Complete Response after “Conversion Surgery” for Initially Unresectable Locally Advanced Intrahepatic Cholangiocarcinoma

We experienced a case of pCR induced by GCS chemotherapy and pembrolizumab monotherapy. Although the direct contribution of pembrolizumab remains unclear, a possible synergistic effect with GCS chemotherapy was suggested, particularly in MSI-H tumors.

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Publication Details

Journal
Surgical Case Reports
Published
2026-01-01
DOI
https://doi.org/10.70352/scrj.cr.25-0569
Primary Topic
Cholangiocarcinoma and Gallbladder Cancer Studies
Type
article
Field-Weighted Citation Impact
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article

A Case of Pathological Complete Response after “Conversion Surgery” for Initially Unresectable Locally Advanced Intrahepatic Cholangiocarcinoma

Takamichi Ishii, Masakazu Fujimoto, Satoshi Ogiso, Hironori Haga et al.
Surgical Case Reports
Cholangiocarcinoma and Gallbladder Cancer Studies
article

A Case of Pathological Complete Response after “Conversion Surgery” for Initially Unresectable Locally Advanced Intrahepatic Cholangiocarcinoma

Takamichi Ishii, Masakazu Fujimoto, Satoshi Ogiso, Hironori Haga, Tomoaki Yoh, Etsuro Hatano, T. Ito, Yasunori Shirakawa
article en

Abstract

We experienced a case of pCR induced by GCS chemotherapy and pembrolizumab monotherapy. Although the direct contribution of pembrolizumab remains unclear, a possible synergistic effect with GCS chemotherapy was suggested, particularly in MSI-H tumors.

Surgical Case ReportsVol. 12(1)
Kyoto University (JP)
Openalex Percentile: Top 94%
Cholangiocarcinoma and Gallbladder Cancer Studies
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