Unveiling the Uncommon: A Rare IgE-Mediated Presentation of Multiple Drug Hypersensitivity Syndrome

Multiple drug hypersensitivity syndrome (MDHS) is characterized by hypersensitivity reactions to two or more unrelated drugs. Although it is commonly associated with delayed reactions, we report a rare case of immediate IgE-mediated MDHS in a 30-year-old female who reacted to levofloxacin and ibuprofen. Both reactions were confirmed through drug challenges, while acetylsalicylic acid was tolerated, excluding COX-1 cross-reactivity. This case highlights the importance of recognizing IgE-mediated MDHS and performing thorough allergy diagnostic workups to ensure accurate management and patient safety.