Therapeutic Alternatives of Trigger Sensitivity Adjustment in Ventilator Induced Diaphragmatic Dysfunction of Critically Ill Patients: A randomized Clinical Trial

Background: Mechanical ventilation (MV) weaning needs to be gradual to bring the patient to independent breathing. Unsuccessful extubation is when a patient needs to be re-intubated in 1-2 days because of the inability to have self-sustainable respiration after artificial removal of airways. Purpose: The goal of the study was to determine the effectiveness of trigger sensitivity adjustment in patients with ventilator induced diaphragmatic dysfunction (VIDD). Materials and Methods: It was a randomized controlled study on the basis of the data recorded to 60 MV patients who would be undergoing planned extubation in the Critical Care Department in Qasr Al-Ainy. Vital signs: heart rate, respiratory rate, blood pressure, oxygen saturation (So2) (2) Arterial blood gases (ABG): PH, PCO2 mmHg, HCO3 m EQ/Liter, PO2 mmHg, (3) Ventilator settings, minute ventilation, tidal volume (before and after the sessions). Results: Table 3 showed the mean ± SD of all the results (PH, Pco2, Hco3, Sao2, minute ventilation [MV], tidal volume [TV], respiratory rate [RR], heart rate [HR], systolic blood pressure [SBP], and diastolic blood pressure [DBP]) during pre- and post-intervention in the two groups. Sao2 (d=1.5) and TV (d=1.06) increased significantly in the sample group, and Pco2 (d=2.5), MV (d=0.65), RR (d=1.43), HR (d=2.29), SBP (d=1.43), and DBP (d=2.04) decreased significantly in the sample group, whereas Sao2 (d=1.94) and Pco2 (d=1.85) increased and HR (d=1. Conclusions: We have concluded that the translational mechanism of weaning of MV could be triggered sensitivity adjustment in ventilator-induced diaphragm dysfunction critically ill patients.