Bisphosphonates use is associated with increased coronary artery calcification in the general population: The Rotterdam study
Long-term bisphosphonate use is associated with increased arterial calcification, most notably with increased CAC, with a dose-response relationship further strengthening this observation. Large-scale observational studies are encouraged to use advanced causal inference methods to evaluate this long-term association and provide additional evidence to strengthen the causal interpretation.
Authors
- Chris Heugens
- Layal Chaker (ORCID: https://orcid.org/0000-0001-7855-5418)
- Maryam Kavousi (ORCID: https://orcid.org/0000-0001-5976-6519)
- Evert van Velsen
- Mitra Nekouei Shahraki (ORCID: https://orcid.org/0000-0002-5921-3591)
- Mare van Overbruggen
- Daniel Bos
- Bruno H. Stricker
Institutions
- Erasmus MC (NL)
Publication Details
- Journal
- Atherosclerosis Plus
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1016/j.athplu.2026.01.001
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Fondation Leducq
- ZonMw
- Erasmus Medisch Centrum