Targeting Macrophage Crosstalk to PASMC by Blunting Inflammatory Phenotype Via SerpinB1 Protects Against Hypoxia-Induced Pulmonary Hypertension
Hypoxia exposure directly amplifies the pro-proliferative crosstalk of macrophages to PASMCs via downregulating SerpinB1 to induce caspase-1 activation and inflammatory phenotype. Targeting macrophage SerpinB1 may hold promise for treating pulmonary hypertension.
Authors
- Jie Liu (ORCID: https://orcid.org/0009-0004-3795-3718)
- Cong Lan (ORCID: https://orcid.org/0000-0002-0538-2488)
- Jiajin Hao
- Guangyao Fang
- Xia Kang (ORCID: https://orcid.org/0000-0002-6978-8516)
- Dachun Yang (ORCID: https://orcid.org/0000-0001-9024-3345)
- Ting Wang
- Ke Peng
- Qiang Wang
- Xiuchuan Li
- Yongjian Yang
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Chengdu Military General Hospital (CN)
- National Institute of Metrology (CN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25832
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00