Metabolite Profiles of Sertraline in Relation to Genotype-Predicted Phenotypes of CYP2B6 and CYP2C19—A Study on 470 Patients
This study demonstrates that α-hydroxy sertraline ketone is mainly formed by CYP2C19, whereas CYP2B6 is the major enzyme responsible for the formation of N-desmethyl sertraline. These novel findings provide a clinical foundation for applying metabolite monitoring as part of sertraline TDM.
Authors
- Marianne Kristiansen Kringen (ORCID: https://orcid.org/0000-0002-4760-1693)
- Line Skute Bråten (ORCID: https://orcid.org/0000-0001-6887-1986)
- Birgit M. Tovik Wollmann
- Espen Molden
Institutions
- OsloMet – Oslo Metropolitan University (NO)
- University of Oslo (NO)
- Diakonhjemmet Hospital (NO)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1097/ftd.0000000000001435
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00