Synthesis of pyridine derivatives using multicomponent reaction of Meldrum acid and KF/Clinoptilolite nanoparticles

Application of catalyst for the synthesis of tetrahydrobenzo[b]pyran prepared by the reaction of Meldrum acid, aromatic or aliphatic aldehydes, and malononitrile in water media. The catalyst was prepared according to a previously published literature procedure using inexpensive and readily available starting materials. Furthermore, the catalyst could be recovered conveniently and reused efficiently such that a considerable catalytic activity still could be achieved after fourth run. Other beneficial features of this new synthetic approach include short reaction time, high yields, clean reaction profiles, and a simple work‐up procedure.