Anti-HER2 treatment in everyday practice: how we treat older women with breast cancer differently

Anti-HER2 therapy use declined substantially after the age of 75 even when accounting for comorbidities and polypharmacy. Chronological age appears important in planning treatment for patients with HER2 + BC. Specific guidelines pertaining to older patients with HER2 + BC are needed to avoid potential undertreatment.

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Publication Details

Journal
Breast Cancer Research and Treatment
Published
2026-01-01
DOI
https://doi.org/10.1007/s10549-025-07888-z
Primary Topic
HER2/EGFR in Cancer Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Anti-HER2 treatment in everyday practice: how we treat older women with breast cancer differently

Sarah Hjorth, Edoardo Botteri, Giske Ursin, K. F. Vandraas et al.
Breast Cancer Research and Treatment
HER2/EGFR in Cancer Research
article

Anti-HER2 treatment in everyday practice: how we treat older women with breast cancer differently

Sarah Hjorth, Edoardo Botteri, Giske Ursin, K. F. Vandraas, B. K. Andreassen, C. B. Trewin-Nybråten, N. C. Støer
article en

Abstract

Anti-HER2 therapy use declined substantially after the age of 75 even when accounting for comorbidities and polypharmacy. Chronological age appears important in planning treatment for patients with HER2 + BC. Specific guidelines pertaining to older patients with HER2 + BC are needed to avoid potential undertreatment.

Breast Cancer Research and TreatmentVol. 215(2)
University of Southern California (US), Oslo University Hospital (NO), Norwegian Institute of Public Health (NO), University of Oslo (NO), Cancer Registry of Norway (NO), Norwegian Womens Public Health Association (NO)
Good health and well-being
Openalex Percentile: Top 95%
HER2/EGFR in Cancer Research
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Anti-HER2 treatment in everyday practice: how we treat older women with breast cancer differently — Sarah Hjorth, Edoardo Botteri, et al. · Breast Cancer Research and Treatment (2026) | TGRS Research Map | TGRS