Aberrant resting-state functional connectivity in medication-naïve generalized anxiety disorder: a whole-brain exploratory fMRI study

This study demonstrates aberrant resting-state functional connectivity in medication-naïve GAD patients, particularly enhanced PCC-SMG rsFC correlated with anxiety severity, suggesting a potential role for interoceptive hypersensitivity in GAD pathophysiology. These findings support the hypothesis of SMG-driven vigilance engaging PCC and mPFC to perpetuate anxiety cycles, warranting future validation with direct interoceptive measures and highlighting neural targets for interventions.