Severe Salmonella Infections in AIGAs Immunodeficiency Syndrome: Hyperinflammation and Immune Dysregulation

This study is the first to define AIGAs-associated <i>Salmonella</i> infection as a distinct clinical syndrome, characterized by severe bacteremia, paradoxical hyperinflammation, universal polymicrobial coinfections, and immune dysregulation. Our findings underscore the critical importance of comprehensive pathogen detection, particularly via NGS, for timely diagnosis and improved patient outcomes.