Derivation of the Hodgkin–Huxley Model

We derive the Hodgkin–Huxley model from a membrane–circuit analogy and extend it to the one-dimensional cable equation. The membrane is treated as a parallel plate capacitor with conductances for Na+, K+, and leak. The Na+ and K+ pathways use m, h, n voltage-dependent gating. The leak term is ungated with a fixed reversal potential. The aim is a concise, consistent derivation that explicitly links the biophysics to the equations. While many graduate-level texts discuss elements of this derivation, in my experience it is difficult to find a contemporary derivation that is both complete—including the cable extension—and conceptually accessible to undergraduate readers.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-07
DOI
https://doi.org/10.5281/zenodo.18168303
Primary Topic
Nanopore and Nanochannel Transport Studies
Type
article
Field-Weighted Citation Impact
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article

Derivation of the Hodgkin–Huxley Model

Nicholas Bader
Zenodo (CERN European Organization for Nuclear Research)
Nanopore and Nanochannel Transport Studies
article

Derivation of the Hodgkin–Huxley Model

Nicholas Bader
article en

Abstract

We derive the Hodgkin–Huxley model from a membrane–circuit analogy and extend it to the one-dimensional cable equation. The membrane is treated as a parallel plate capacitor with conductances for Na+, K+, and leak. The Na+ and K+ pathways use m, h, n voltage-dependent gating. The leak term is ungated with a fixed reversal potential. The aim is a concise, consistent derivation that explicitly links the biophysics to the equations. While many graduate-level texts discuss elements of this derivation, in my experience it is difficult to find a contemporary derivation that is both complete—including the cable extension—and conceptually accessible to undergraduate readers.

Zenodo (CERN European Organization for Nuclear Research)
Quality Education
Openalex Percentile: Top 94%
Nanopore and Nanochannel Transport Studies
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Derivation of the Hodgkin–Huxley Model — Nicholas Bader · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS