An aryl-hydrocarbon receptor-based drug-screening strategy for hepatocellular carcinoma based on dynamic fluorescence imaging
The development of fluorescence imaging-based drug-screening methods is crucial. We devised an AhR-specific platform AhRPH (LOD = 8.7 ng mL<sup>-1</sup>), which consists of vitamin-A functionalized liposomes targeting HSCs and encapsulating AhR-specific probes (ArP). It distinguished drug efficacy: sorafenib/lenvatinib boosted AhR (resistance), and regorafenib suppressed it. This method is specific/sensitive but has limited <i>in vivo</i> depth.
Authors
- Pengfei Shi (ORCID: https://orcid.org/0000-0003-4297-5714)
- Weiru Yan
- Shusheng Zhang (ORCID: https://orcid.org/0000-0002-8416-8331)
- Chuanchen Wu
- Weiyao Sun (ORCID: https://orcid.org/0009-0004-5330-3037)
- Junyan Li
- Yihong Sun
Institutions
- Linyi University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1039/d5cc07101a
- Primary Topic
- Molecular Sensors and Ion Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00