A Rare Case of Necrotising Sarcoid Granulomatosis Presenting as Bilateral Pulmonary Masses Mimicking Malignancy

Necrotising sarcoid granulomatosis (NSG) is a rare granulomatous lung disease characterised by non-caseating granulomas, necrosis, and vasculitis. We describe a 50-year-old man who presented with constitutional symptoms and bilateral pulmonary masses initially suggestive of metastatic malignancy. Extensive infectious, malignant, and autoimmune workup was negative. Histopathology from lung biopsies and a video-assisted thoracoscopic surgery (VATS) resection revealed granulomatous inflammation with necrosis and no evidence of malignancy or infection. A trial of corticosteroids resulted in clinical, biochemical, and radiological improvement. This case highlights the diagnostic challenges of NSG and the importance of multidisciplinary evaluation to avoid misdiagnosis.

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Publication Details

Journal
Respirology Case Reports
Published
2026-01-01
DOI
https://doi.org/10.1002/rcr2.70449
Primary Topic
Sarcoidosis and Beryllium Toxicity Research
Type
article
Field-Weighted Citation Impact
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article

A Rare Case of Necrotising Sarcoid Granulomatosis Presenting as Bilateral Pulmonary Masses Mimicking Malignancy

Jacqueline W. Chung, Ayan Sabih, Rory O’Donnell
Respirology Case Reports
Sarcoidosis and Beryllium Toxicity Research
article

A Rare Case of Necrotising Sarcoid Granulomatosis Presenting as Bilateral Pulmonary Masses Mimicking Malignancy

Jacqueline W. Chung, Ayan Sabih, Rory O’Donnell
article en

Abstract

Necrotising sarcoid granulomatosis (NSG) is a rare granulomatous lung disease characterised by non-caseating granulomas, necrosis, and vasculitis. We describe a 50-year-old man who presented with constitutional symptoms and bilateral pulmonary masses initially suggestive of metastatic malignancy. Extensive infectious, malignant, and autoimmune workup was negative. Histopathology from lung biopsies and a video-assisted thoracoscopic surgery (VATS) resection revealed granulomatous inflammation with necrosis and no evidence of malignancy or infection. A trial of corticosteroids resulted in clinical, biochemical, and radiological improvement. This case highlights the diagnostic challenges of NSG and the importance of multidisciplinary evaluation to avoid misdiagnosis.

Respirology Case ReportsVol. 14(1)
Waikato Hospital (NZ)
Openalex Percentile: Top 95%
Sarcoidosis and Beryllium Toxicity Research
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