Oral and anal shedding of <i>Treponema pallidum</i> in patients with syphilis in the DOXYVAC cohort
This study shows that a significant proportion of patients have oral or anal TP excretion, sometimes several months before serological diagnosis, suggesting potential early asymptomatic transmission. The integration of the TP PCR assay into routine screening of high-risk MSM could enable earlier detection and treatment of these patients. The absence of doxycycline resistance is reassuring, but continued monitoring remains essential.
Authors
- P. Grange (ORCID: https://orcid.org/0000-0001-8151-748X)
- Nadjet Benhaddou (ORCID: https://orcid.org/0000-0002-5356-8172)
- Valentin Leducq (ORCID: https://orcid.org/0000-0002-6817-6227)
- Romain Salle (ORCID: https://orcid.org/0000-0003-4411-7289)
- Lambert Assoumou (ORCID: https://orcid.org/0000-0002-5547-1796)
- Nicolas Dupin (ORCID: https://orcid.org/0000-0003-3775-5629)
- Jean-Michel Molina
- Jade Ghosn (ORCID: https://orcid.org/0000-0003-0274-5199)
- Moussa Ouattara
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Délégation Paris 5 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Saint Louis University Hospital (US)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Laboratoire National de Référence (MA)
- Hôpital Lariboisière (FR)
- Pitié-Salpêtrière Hospital (FR)
- Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR)
- Institut Cochin (FR)
- Hôpital Saint-Louis (FR)
- Hôpital Bichat-Claude-Bernard (FR)
Publication Details
- Journal
- Sexually Transmitted Infections
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1136/sextrans-2025-056712
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00