Anti-obesity effects of fucoxanthin and conjugated linoleic acid complex liposomes in high-fat diet mice through regulation of AMPK signaling pathway

Solving the problem of obesity has been globally recognized as a crucial public health challenge. Recent studies have shown that fucoxanthin and conjugated linoleic acid could work together to exert an anti-obesity effect. In this study, sodium alginate- and chitosan-modified fucoxanthin and conjugated linoleic acid complex liposome (S-C-L) was prepared and characterized. The anti-obesity effect and mechanism of action of S-C-L were evaluated by establishing an obese mouse model. The results indicated that S-C-L reduced the weight and fat content of obese mice and improved their oxidative stress state. It regulated the expression levels of mRNA and protein by activating the AMPK signaling pathway, thereby enhancing energy expenditure and inhibiting the differentiation of adipocytes, confirming its anti-obesity properties. Comprehensive analysis indicated that S-C-L had broad application potential in the development of anti-obesity foods and health products.