Grey‐White matter contrast as an early brain pathology marker in Familial Alzheimer's disease

GWC is associated with disease stage and proximity to onset during the 20 years prior to symptoms manifesting; a crucial window for AD therapeutic trials. While cortical thickness measures can detect atrophy in the symptomatic disease stage of AD, it appears less able than GWC to track changes during presymptomatic stages. While the influence of factors such as age and amyloid related inflammation require further investigation, GWC shows promise as an easily accessible clinical MRI tool for disease staging and tracking during the years preceding clinical onset.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_104802
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Grey‐White matter contrast as an early brain pathology marker in Familial Alzheimer's disease

Helen Rice, Philip SJ. Weston, Lloyd Prosser, Duncan Alston et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Grey‐White matter contrast as an early brain pathology marker in Familial Alzheimer's disease

Helen Rice, Philip SJ. Weston, Lloyd Prosser, Duncan Alston, Leonard Pieperhoff, Damien Ferguson, Frederik Barkhof, Tiago Gil Oliveira, Antoinette O'Connor, Ian B. Malone, Nick C Fox
article en

Abstract

GWC is associated with disease stage and proximity to onset during the 20 years prior to symptoms manifesting; a crucial window for AD therapeutic trials. While cortical thickness measures can detect atrophy in the symptomatic disease stage of AD, it appears less able than GWC to track changes during presymptomatic stages. While the influence of factors such as age and amyloid related inflammation require further investigation, GWC shows promise as an easily accessible clinical MRI tool for disease staging and tracking during the years preceding clinical onset.

Alzheimer s & DementiaVol. 21(S2)
Trinity College Dublin (IE), UK Dementia Research Institute (GB), NIHR Queen Square Dementia Biomedical Research Unit (GB), National Hospital for Neurology and Neurosurgery (GB), Amsterdam University Medical Centers (NL), St. James's Hospital (IE), University College London (GB), Vrije Universiteit Amsterdam (NL), University of Amsterdam (NL), University of Minho (PT)
Openalex Percentile: Top 29%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Grey‐White matter contrast as an early brain pathology marker in Familial Alzheimer's disease — Helen Rice, Philip SJ. Weston, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS