Synthesis of thiazoles from multicomponent reaction of alkyl bromides

An efficient synthesis of ethyl 2-(4-aryl-2-dialkylamino-1,3-thiazole-5-yl)-2-oxoacetates is described via an one-pot reaction between acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate.

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Publication Details

Published
2025-12-24
DOI
https://doi.org/10.82361/iranjoc.2025.1229265
Primary Topic
Multicomponent Synthesis of Heterocycles
Type
article
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article

Synthesis of thiazoles from multicomponent reaction of alkyl bromides

IAU
Multicomponent Synthesis of Heterocycles
article

Synthesis of thiazoles from multicomponent reaction of alkyl bromides

IAU
article en

Abstract

An efficient synthesis of ethyl 2-(4-aryl-2-dialkylamino-1,3-thiazole-5-yl)-2-oxoacetates is described via an one-pot reaction between acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate.

Clean water and sanitation
Openalex Percentile: Top 32%
Multicomponent Synthesis of Heterocycles
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Synthesis of thiazoles from multicomponent reaction of alkyl bromides — IAU · (2025) | TGRS Research Map | TGRS