High‑intensity focused ultrasound in the multimodal treatment of colorectal cancer liver metastases: A case report

Colorectal liver metastasis (CRLM) is typically associated with a poor prognosis. However, adopting multiple comprehensive treatment methods can significantly improve patients' long-term survival rates. High-intensity focused ultrasound (HIFU) is an emerging therapeutic technique that presents new treatment possibilities for patients. The present study reports the case of a patient who was diagnosed with liver metastasis following laparoscopic rectal cancer surgery. After unsuccessful tumor control with classical chemotherapy, radiofrequency ablation and interventional embolization therapy, the patient underwent HIFU treatment, which resulted in complete tumor remission and >10 years of tumor-free survival. In this case, HIFU treatment significantly improved tumor control without causing additional trauma. This case highlights a successful multimodal treatment approach for CRLM and provides valuable insights for similar cases, underscoring the importance of personalized treatment that integrates multiple therapeutic modalities. As a non-invasive and innovative technique, HIFU demonstrates significant potential in providing a new avenue for the future treatment of CRLM.