Combined Large Cell Neuroendocrine Carcinoma With Enteric‐Type Adenocarcinoma of the Lung

Reported herein is an extremely rare case of combined LCNEC with enteric-type adenocarcinoma of the lung (EAL) in a 72-year-old male. The LCNEC component was further divided into two subcomponents, based on cohesiveness and immunohistochemical characteristics. Overall, the heterogeneity of this tumor demonstrated an unusual histologic pattern of combined LCNEC.

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Publication Details

Journal
Pathology International
Published
2026-01-01
DOI
https://doi.org/10.1111/pin.70080
Primary Topic
Neuroendocrine Tumor Research Advances
Type
article
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article

Combined Large Cell Neuroendocrine Carcinoma With Enteric‐Type Adenocarcinoma of the Lung

Hiroshi Hashimoto, Kimiya Sato, Susumu Matsukuma, K. KAMEDA et al.
Pathology International
Neuroendocrine Tumor Research Advances
article

Combined Large Cell Neuroendocrine Carcinoma With Enteric‐Type Adenocarcinoma of the Lung

Hiroshi Hashimoto, Kimiya Sato, Susumu Matsukuma, K. KAMEDA, Kazuyuki Komori, Motohiro Tsuchiya
article en

Abstract

Reported herein is an extremely rare case of combined LCNEC with enteric-type adenocarcinoma of the lung (EAL) in a 72-year-old male. The LCNEC component was further divided into two subcomponents, based on cohesiveness and immunohistochemical characteristics. Overall, the heterogeneity of this tumor demonstrated an unusual histologic pattern of combined LCNEC.

Pathology InternationalVol. 76(1)
National Defense Medical College Hospital (JP), Saiseikai Utsunomiya hospital (JP), Self-Defense Forces Central Hospital (JP), National Defense Medical College (JP)
Good health and well-being
Openalex Percentile: Top 95%
Neuroendocrine Tumor Research Advances
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