Assessment of a Modified High‐Dimensional Propensity Score Approach for <scp>UK</scp> Electronic Health Record Data: Evaluating Upper Gastrointestinal Safety of <scp>NSAIDs</scp> and <scp>COX</scp> ‐2 Inhibitors
We demonstrate the ability of the modified-HDPS to obtain similar results to comparable pharmacoepidemiological studies and randomised trials, highlighting the potential benefit of these approaches in UK EHRs more widely and the value of adding hospital data to enrich the pool of covariates available for the HDPS algorithm.
Authors
- John Tazare (ORCID: https://orcid.org/0000-0002-7194-2615)
- Liam Smeeth (ORCID: https://orcid.org/0000-0002-9168-6022)
- Daniel C. Gibbons (ORCID: https://orcid.org/0000-0002-3769-9535)
- Marianne Cunnington (ORCID: https://orcid.org/0009-0002-2398-2281)
- Ian Douglas (ORCID: https://orcid.org/0000-0002-8970-1406)
- Iain Gillespie (ORCID: https://orcid.org/0000-0002-2265-9506)
- John Logie
- Elizabeth J. Williamson
- M. Sanni Ali
Institutions
- World Energy Council (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Institute of Group Analysis (GB)
Publication Details
- Journal
- Pharmacoepidemiology and Drug Safety
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/pds.70319
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00