Transient Gastric Pressure Elevation Synergizing With Impaired Esophagogastric Junction Barrier Function Plays a Pivotal Role in the Refractory Gastroesophageal Reflux Disease
: Transient gastric pressure elevation and compromised EGJ barrier function drive weakly acidic reflux and esophageal bolus exposure. This pressure gradient-barrier mismatch underpins the refractoriness of RGERD.
Authors
- Y. C. Ge
- Tianzhuang Li
- Lingling Zhu
- Zhijie Xu (ORCID: https://orcid.org/0009-0004-9492-8420)
- Zihan Xia
- Liping Duan
- Xin Huang
- Xiaolin Ji
- Kun Wang
- Yuzhu Chen
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Journal of Neurogastroenterology and Motility
- Published
- 2026-01-06
- DOI
- https://doi.org/10.5056/jnm25050
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00