Striatal dopamine synthesis capacity in Parkinson’s disease: Effects of age, sex, and body mass index in a large [18F]fluorodopa PET cohort
Dopamine synthesis capacity is independently affected by PD and demographic factors and correlated between the striatal and thalamic regions in both controls and PD patients. Adjusting for scanner effects in multi-scanner datasets is recommended. When subject-specific MRI is unavailable, atlas-based normalization may be used with caution to prevent major data loss.
Authors
- Severi Santavirta (ORCID: https://orcid.org/0000-0001-7538-9549)
- Jouni Tuisku (ORCID: https://orcid.org/0000-0003-0965-9365)
- J. Hietala
- Tuulia Malén (ORCID: https://orcid.org/0000-0001-9357-6364)
- Janne Isojärvi (ORCID: https://orcid.org/0000-0003-0397-7629)
- Sakari Kaasalainen
- Lauri Nummenmaa
- Valtteri Kaasinen
- Marco Bucci
- Juha Rinne
Institutions
- University of Turku (FI)
- Turku University Hospital (FI)
- Turku PET Centre (FI)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.nicl.2026.103944
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00