LOXL2⁺ cancer-associated fibroblasts shape WNT signaling to drive chemoresistance and poor outcomes in colorectal cancer: Insights from multi-omics and epidemiological analyses
Our integrative epidemiological and experimental analyses identify LOXL2⁺ CAFs as a key stromal determinant of chemoresistance and poor prognosis in CRC. These findings highlight a clinically relevant stromal biomarker with potential for risk stratification and therapeutic targeting in colorectal cancer.
Authors
- Qiangqiang Fu (ORCID: https://orcid.org/0000-0001-7784-8868)
- Chengyuan Xu (ORCID: https://orcid.org/0000-0002-2149-9934)
- Tengfei Li (ORCID: https://orcid.org/0009-0004-4435-7527)
- Qin Zhang
- Shanshan Cai
- Siqi Zhang
- Lin Zhang
Institutions
- Tongji University (CN)
- Tongji Hospital (CN)
- Yangpu Hospital of Tongji University (CN)
- Lancaster University (GB)
Publication Details
- Journal
- Neoplasia
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1016/j.neo.2025.101267
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00