Nephroprotective and Antioxidant Effects of Mutrakrichantak Churna in Cisplatin-Induced Nephrotoxicity in Rats

Cisplatin-induced nephrotoxicity (CIN) significantly hampers the therapeutic potency of cisplatin because of renal oxidative stress, inflammation, and apoptosis. This study investigates the nephroprotective and antioxidant potential of Planet Ayurveda Mutrakrichantak Churna (PAMC), a polyherbal Ayurvedic formulation, in a CIN model using Wistar albino rats. PAMC was administered at low (200 mg/kg) and high (400 mg/kg) doses and compared to a standard nephroprotective treatment (Cystone syrup). The results showed a dose-related improvement in renal function and oxidative stress markers. PAMC significantly reduced serum creatinine, urea, uric acid, and malondialdehyde levels while enhancing antioxidant enzyme activities, including SOD, CAT, and Gpx. Histopathological analysis showed preserved renal architecture, decreased tubular necrosis, and less inflammation, especially at the higher dose of PAMC, which was equivalent to standard treatment. This study suggests the potency of PAMC to be an effective nephroprotective agent that involves mechanisms not only antioxidant but also anti-inflammatory against the insults of CIN. This inherent composition and broad spectrum of action make PAMC a suitable adjunct in chemotherapy regimens to avert renal injury. Hence, further clinical studies may be necessary to verify and determine long-term patient safety and efficacy.