A lipid nanoparticle encapsulated CPA-CTD mRNA vaccine provides protection against Clostridium perfringens-driven diseases
These results demonstrate that the CPA-CTD mRNA vaccine provides rapid and robust immune protection against <i>C. perfringens</i> alpha-toxin-associated diseases, with promising potential for applications in both veterinary and human health.
Authors
- Qi Jia
- Wanbo Tai (ORCID: https://orcid.org/0000-0002-9864-8993)
- Jing Wang
- Chao Sun
- Xin Yin
- Ting Le
- Jitao Chang
- Haoyu Xiang
- Fang Wang
- Zhigang Jiang
Institutions
- University of Liège (BE)
- Ningxia University (CN)
- Gembloux Agro-Bio Tech (BE)
- Shenzhen Bay Laboratory (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Harbin Veterinary Research Institute (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1748171
- Citations
- 1
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 32.78
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China