G-CSF promotes H3K27ac-modified KLF5 to activate CXCR4 expression and drive colon cancer growth and metastasis
G-CSF drives CC progression by enhancing H3K27ac-dependent upregulation of KLF5, which transactivates CXCR4 to promote EMT, proliferation and metastasis. Targeting the G-CSF/KLF5/CXCR4 axis may represent a potential therapeutic strategy for advanced CC.
Authors
- Wenhao Wu (ORCID: https://orcid.org/0000-0002-2244-6543)
- Wufeng Fan
- Guoqing Ma
- Tingting He (ORCID: https://orcid.org/0000-0002-3275-7732)
- Tianbao Wang
- Canhui Jin
- Jing Jiang
- Ping Zhou
Institutions
- Shenzhen University (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Anshan Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s40001-025-03613-0
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00