Effect of BALF-based mNGS on clinical outcomes of immunocompromised subjects with opportunistic pulmonary infections: a multicenter propensity score-matched study
Our study indicated that early BALF mNGS testing upon admission was associated with improved OI up to day 7, clinical improvement on day 14, and decreased 21-day mortality. These benefits are likely facilitated by the higher diagnostic yield of mNGS and its direct impact on guiding targeted antibiotic therapy.
Authors
- Yan Wu (ORCID: https://orcid.org/0000-0002-6693-9657)
- Shiying Guo (ORCID: https://orcid.org/0000-0002-7772-7190)
- Anqi Wang (ORCID: https://orcid.org/0000-0002-3369-1499)
- Jiajia Wang (ORCID: https://orcid.org/0000-0002-0554-1354)
- Dong Qiu
- Shuguang Han
- Cheng Chen
- Suping Tang
- Linlin Wang
- Xiaoyan Sai
Institutions
- Jiangnan University (CN)
- Soochow University (CN)
- Wuxi Fourth People's Hospital (CN)
- Taizhou First People's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fcimb.2025.1724935
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Major Project