Genetic Architecture of Comorbidity Between Chronic Obstructive Pulmonary Disease and Cardiovascular Diseases: Exploring Shared Mechanisms and Potential Therapeutic Targets
This study provides genetic evidence for shared mechanisms linking COPD with HTN, CHD, and HF. It highlights the roles of neurotransmitter receptors, iron metabolism, vascular development, and energy metabolism in COPD-CVD comorbidity. These findings offer insights into precision prevention and therapeutic strategies targeting COPD-CVD comorbidity.
Authors
- S. R. Wayne Chen (ORCID: https://orcid.org/0000-0002-4421-5906)
- Xiaojian Li (ORCID: https://orcid.org/0000-0002-9131-4659)
- Rongfang Xie (ORCID: https://orcid.org/0000-0001-8922-2766)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- International Journal of COPD
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/copd.s572586
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Education Department of Jiangxi Province