Integrated screens reveal that guanine nucleotide depletion, which is irreversible via targeting IMPDH2, inhibits pancreatic cancer and potentiates KRAS inhibition
These findings provide a rationale for developing combination therapies targeting KRAS and DNGB, highlighting the potential of purine nucleotide imbalance as a biomarker to guide the application of these therapies.
Authors
- Si Shi
- Chunbin Zhu (ORCID: https://orcid.org/0009-0008-9580-6600)
- H. Eric Xu (ORCID: https://orcid.org/0000-0002-6829-8144)
- Y. Liu
- Haoqi Pan
- Sikai Wang
- Mingming Xiao
- X J Yu
- Di Wu
- Jin Xu
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Cancer Institute (CN)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Gut
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1136/gutjnl-2025-336235
- Citations
- 2
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 44.47