Neuropsychiatric Sequelae of Chronic Rhinosinusitis: A Retrospective Cohort Study Using a Multi-institutional Electronic Health Records Network

CRSwNP is associated with a significantly lower risk of several psychiatric disorders compared to CRSsNP, potentially due to differences in underlying inflammatory pathways or treatment effects. These findings support the integration of psychiatric screening in CRS management and warrant further investigation into immune modulation as a potential strategy to reduce neuropsychiatric risk.