An exploration of the relationships between the effects of psilocybin on behavior, 5-HT <sub>2A</sub> receptor occupancy, and neuroplastic effects in mice
These findings suggest that the therapeutic effects of psilocybin could be mediated by dose- and region-specific enhancement of neuronal plasticity, with distinct signatures associated with anxiolytic-like and antidepressant-like properties.
Authors
- Joseph R. Hedde (ORCID: https://orcid.org/0000-0002-6031-754X)
- Adam K. Klein (ORCID: https://orcid.org/0000-0002-1640-9324)
- Enya Paschen (ORCID: https://orcid.org/0000-0001-6323-3889)
- Connor J. Maltby (ORCID: https://orcid.org/0000-0003-2746-9055)
- Ashley N. Hanks
- Dino Dvořák (ORCID: https://orcid.org/0000-0003-3884-1393)
- Zoe Hughes
- Massimiliano Bianchi
- Jessica Pinto
Institutions
- Pioneer (United States) (US)
- Translational Research in Oncology (FR)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1177/02698811251395386
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00