Risk-Reducing Bilateral Mastectomy and Mortality in Carriers of <i>BRCA1</i> and <i>BRCA2</i> Variants
Risk-reducing bilateral mastectomy was associated with lower overall and breast cancer-specific mortality in carriers of the BRCA variants. These findings support the role of risk-reducing bilateral mastectomy as a potentially life-extending intervention and may inform the shared decision-making discussions in these women.
Authors
- Matthew G. Davey (ORCID: https://orcid.org/0000-0002-9892-9920)
- Alexandra Zaborowski (ORCID: https://orcid.org/0000-0002-0894-4079)
- Damian McCartan (ORCID: https://orcid.org/0000-0002-2488-095X)
- Claire Rutherford (ORCID: https://orcid.org/0000-0001-6045-0124)
- Jennifer McGarry (ORCID: https://orcid.org/0000-0002-1493-7385)
- Denis Evoy
- Ruth Prichard
- Clare Oreilly
- J. Rothwell
- Michael R. Boland
Institutions
- St. Vincent's University Hospital (IE)
Publication Details
- Journal
- JAMA Surgery
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1001/jamasurg.2025.5929
- Citations
- 1
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 30.93