In vitro Screening for Synergistic Polymyxin B-Based Combinations Against KPC- Producing Carbapenem-Resistant Klebsiella pneumoniae
This study demonstrated that combinations of polymyxin B with tigecycline, imipenem, ceftazidime, or cefepime show promising therapeutic potential against KPC-producing CRKP. Further studies are warranted to evaluate their in vivo efficacy.
Authors
- Feifan Xie (ORCID: https://orcid.org/0000-0002-9038-2676)
- Yi Liu (ORCID: https://orcid.org/0000-0002-1058-0382)
- Sanwang Li (ORCID: https://orcid.org/0000-0001-5979-5133)
- Yehua Xie
- Menghan Lv
- Hanxi Yi
- Zeneng Cheng
Institutions
- Central South University (CN)
- SGIDI Engineering Consulting (China) (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/dddt.s574985
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province