Treosulfan-based conditioning strategies in older or frail patients undergoing allogeneic hematopoietic cell transplantation
Treosulfan is a safe and effective agent for conditioning in older or comorbid allo-HCT recipients, exhibiting comparable or superior survival outcomes compared to reduced intensity regimens and busulfan, with similar or lower rates of graft-versus-host disease and reduced non-relapse mortality. Before allo-HCT, geriatric assessment and evaluation of the underlying comorbidities are important for the selection of a personalized conditioning regimen.
Authors
- Eleni Gavriilaki (ORCID: https://orcid.org/0000-0002-8883-8208)
- Paschalis Evangelidis (ORCID: https://orcid.org/0000-0003-1783-5111)
- Anna Papakonstantinou (ORCID: https://orcid.org/0000-0001-9372-155X)
- Ioanna Sakellari (ORCID: https://orcid.org/0000-0003-4325-8856)
- Grigorios Salvaras
- Iraklis Leonidis
- Anna Vardi
Institutions
- Aristotle University of Thessaloniki (GR)
- G. Papanikolaou General Hospital (GR)
Publication Details
- Journal
- Expert Review of Hematology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1080/17474086.2026.2613738
- Citations
- 1
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 35.41