Breviscapine enhances angiogenesis in diabetic wound healing by regulating macrophage polarization via mitochondrial metabolic reprogramming
This study provides the first evidence that breviscapine accelerates DU wound repair by inhibiting mitochondrial metabolism reprogramming mediated by the Arg2 and downstream HIF-1α pathway, restoring macrophage M2 polarization and enhancing angiogenesis, with important implications for precision immunometabolic therapy of DU.
Authors
- Shuai Shao (ORCID: https://orcid.org/0000-0001-5320-8823)
- Hongyun Niu
- Jing Chen
- Huiqin Xu
- Tianning Long
- Yuping Chen
- Anmei Shu
- Tingyu Ding
- Hongyan Wu
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Vocational College of Medicine (CN)
- Yancheng Institute of Technology (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.phymed.2026.157794
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00