Long‐term immune reconstitution patterns and influencing factors in people living with <scp>HIV</scp> exhibiting suboptimal immune response after 24 months of antiretroviral therapy

People living with HIV with suboptimal early immune responses exhibit three distinct immune recovery trajectories. Higher baseline CD4<sup>+</sup> T cell levels favour long-term reconstitution, whereas transient viremia may predict persistent immune failure.

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Publication Details

Journal
HIV Medicine
Published
2026-01-05
DOI
https://doi.org/10.1111/hiv.70192
Primary Topic
HIV Research and Treatment
Type
article
Field-Weighted Citation Impact
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article

Long‐term immune reconstitution patterns and influencing factors in people living with HIV exhibiting suboptimal immune response after 24 months of antiretroviral therapy

Qing Xiao, F. Zhang, Lin Tuo, Liting Yan et al.
HIV Medicine
HIV Research and Treatment
article

Long‐term immune reconstitution patterns and influencing factors in people living with HIV exhibiting suboptimal immune response after 24 months of antiretroviral therapy

Qing Xiao, F. Zhang, Lin Tuo, Liting Yan, Naijuan Yao, Xuemei Chen, Kaiju Xu, Shuqiang Wang, Ying Liu, Xingxiang Yang
article en

Abstract

People living with HIV with suboptimal early immune responses exhibit three distinct immune recovery trajectories. Higher baseline CD4<sup>+</sup> T cell levels favour long-term reconstitution, whereas transient viremia may predict persistent immune failure.

HIV Medicine
University of Electronic Science and Technology of China (CN), Beijing Ditan Hospital (CN), Chongqing Cancer Hospital (CN)
Good health and well-being
Openalex Percentile: Top 95%
HIV Research and Treatment
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