Garadacimab-gxii—A Novel Prophylactic Treatment for Hereditary Angioedema: A Drug Review

Garadacimab reduces the frequency of HAE attacks with a safety profile comparable with existing prophylactic treatments. Its mechanism of targeting activated factor XII offers an alternative approach to HAE management. Ongoing monitoring and post-marketing data may further define its role in clinical practice.

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Publication Details

Journal
Annals of Pharmacotherapy
Published
2026-01-07
DOI
https://doi.org/10.1177/10600280251405482
Primary Topic
Coagulation, Bradykinin, Polyphosphates, and Angioedema
Type
article
Field-Weighted Citation Impact
0.00
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article

Garadacimab-gxii—A Novel Prophylactic Treatment for Hereditary Angioedema: A Drug Review

Steven R. Feldman, Omar Raheel, Anette Bygum, Kelli M Schindel et al.
Annals of Pharmacotherapy
Coagulation, Bradykinin, Polyphosphates, and Angioedema
article

Garadacimab-gxii—A Novel Prophylactic Treatment for Hereditary Angioedema: A Drug Review

Steven R. Feldman, Omar Raheel, Anette Bygum, Kelli M Schindel, Natalie Behzadpour, Chenan A. Huang, Vivian Le
article en

Abstract

Garadacimab reduces the frequency of HAE attacks with a safety profile comparable with existing prophylactic treatments. Its mechanism of targeting activated factor XII offers an alternative approach to HAE management. Ongoing monitoring and post-marketing data may further define its role in clinical practice.

Annals of Pharmacotherapy
University of Kansas (US), University of Southern Denmark (DK), Wake Forest University (US)
Openalex Percentile: Top 94%
Coagulation, Bradykinin, Polyphosphates, and Angioedema
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