Evaluating the impact of adrenalectomy and mineralocorticoid receptor antagonists for primary aldosteronism on left ventricular remodeling: a systematic review and meta-analysis
This meta-analysis suggests that both adrenalectomy and MRAs improve LV remodeling. Although adrenalectomy was generally associated with slightly greater LVMI reductions than MRAs, the impact of optimized MRA therapy on LVMI reduction remains uncertain. When focusing specifically on patients with unilateral PA, adrenalectomy was associated with more pronounced regression of LV remodeling compared with MRA therapy.
Authors
- Uei-Lin Chen (ORCID: https://orcid.org/0000-0003-3440-5180)
- Z. Y. Chen
- Yen-Hung Lin
- C J Liao
- Jenifer M. Brown (ORCID: https://orcid.org/0000-0002-6647-639X)
- Cheng-Hsuan Tsai
- Yu‐Cheng Chang (ORCID: https://orcid.org/0000-0002-9634-8380)
- Chi-Sheng Hung
- Anand Vaidya
- Vin-Cent Wu
Institutions
- Brigham and Women's Hospital (US)
- National Taiwan University (TW)
- Min Sheng General Hospital (TW)
- National Taiwan University Hospital (TW)
- National Hsinchu University of Education (TW)
- National Yunlin University of Science and Technology (TW)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1093/ejendo/lvaf271
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 30.73