Association between systemic inflammatory response index and cardiovascular disease risk in rheumatoid arthritis patients: a machine learning based on US and Chinese cohorts

SIRI is significantly and positively associated with CVD risk in RA and effectively enhances the predictive performance of the Framingham risk score when applied to this population. Accordingly, SIRI may serve as an inflammatory biomarker for the early identification and management of CVD risk in RA, thereby informing the development of individualized therapeutic strategies. Key Points • SIRI is significantly and positively associated with CVD risk in RA. • SIRI enhances the predictive performance of the Framingham risk score when applied to RA patients.