Sensor-based quantification of items used in the MDS-UPDRS-III scale: repetitive lower-limb movements in healthy human participants

Reference values could be determined for all parameters including smoothness and acceleration patterns. The quantitative assessment of two MDS-UPDRS-III items shows that temporal changes and adaptation-mechanisms significantly influenced leg-movement dynamics. Reducing exercise duration to 10 s and implementing a metronome with defined frequency could enhance measurement accuracy and reliability, offering more precise parameters for future applications in PD-patients.