Feasibility and Implementation of INTERVAL-GAP4: A Global Randomised Controlled Trial of Intense Hybrid-supervised/Self-managed Versus Self-directed Exercise for Metastatic Prostate Cancer
In this report, we describe the feasibility of a centrally coordinated, global clinical trial of hybrid-supervised/self-managed versus self-directed exercise for men with metastatic prostate cancer. We report trial implementation as mixed across the world, while exercise session adherence was high among men receiving the intervention. However, of the patients approached, 53% declined to participate in the study, and those enrolled were likely more motivated and willing to exercise. Those who participated varied in age, had other health conditions, were receiving multiple medications, and were at different treatment stages after a diagnosis of metastatic prostate cancer. Recent guidelines provide a framework for integrating exercise programming into clinical care for patients with advanced cancer. Further implementation science research is needed to help patients with advanced cancer exercise safely and effectively as part of their cancer care.
Authors
- Mieke Van Hemelrijck (ORCID: https://orcid.org/0000-0002-7317-0858)
- M. Pollak
- Stephen P. Finn (ORCID: https://orcid.org/0000-0002-8628-5814)
- Sam McKeown
- Charles J. Ryan (ORCID: https://orcid.org/0000-0002-2081-3557)
- Robert Usher Newton (ORCID: https://orcid.org/0000-0003-0302-6129)
- Stephan Praet (ORCID: https://orcid.org/0000-0001-6714-9027)
- James W.F. Catto (ORCID: https://orcid.org/0000-0003-2787-8828)
- Tina L. Skinner (ORCID: https://orcid.org/0000-0002-5704-2741)
- Daniel C. Hughes (ORCID: https://orcid.org/0000-0002-2224-9347)
- Harriet Wylie (ORCID: https://orcid.org/0000-0002-8183-4853)
- Kerry S. Courneya (ORCID: https://orcid.org/0000-0002-9677-3918)
- Emer Guinan (ORCID: https://orcid.org/0000-0001-9715-146X)
- Daniel A. Galvão (ORCID: https://orcid.org/0000-0002-8209-2281)
- Jennette D. Sison
- Stephen R. Plymate (ORCID: https://orcid.org/0000-0002-7597-6943)
- Freerk T. Baumann (ORCID: https://orcid.org/0000-0002-4450-7351)
- Stacey A. Kenfield (ORCID: https://orcid.org/0000-0002-1585-7352)
- Rosemary Greenwood (ORCID: https://orcid.org/0000-0001-6637-5225)
- Gillian Prue (ORCID: https://orcid.org/0000-0003-2198-3731)
- June M. Chan (ORCID: https://orcid.org/0000-0002-7620-569X)
- Sarah Rudman (ORCID: https://orcid.org/0000-0001-9447-8985)
- Nicolas H. Hart
- Elizabeth Kessler
- Leah Ung
- Suneil Jain
- Moritz Schumann
- Jeff Coombes
- Alan Hayes
- Arash Asher
- Li Zhang
- Erin L. Van Blarigan
- Wilhelm Bloch
- Lorelei A. Mucci
- Colleen Nelson
- Kerri Winters-Stone
- Fred Saad
- Hans Bussmann
- Ralph Manders
Institutions
- University of Technology Sydney (AU)
- Edith Cowan University (AU)
- Memorial Sloan Kettering Cancer Center (US)
- German Sport University Cologne (DE)
- University of Alberta (CA)
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- Flinders University (AU)
- University of California, San Francisco (US)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Chemnitz University of Technology (DE)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Men's Health Forum (GB)
- Centre Hospitalier de l’Université de Montréal (CA)
- University Hospitals Bristol and Weston NHS Foundation Trust (GB)
- University of Sheffield (GB)
- The University of Notre Dame Australia (AU)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1016/j.euros.2025.12.001
- Primary Topic
- Cancer survivorship and care
- Type
- article
- Field-Weighted Citation Impact
- 0.00