Design and Engineering of Recombinant Oncolytic Adenoviruses Expressing an Anti-EpCAM/Anti-CD3 BiTE for Targeted Immunotherapy of A549 Lung Cancer Cells
The results indicate that equipping OVs with BiTE molecules may address critical challenges in virotherapy by enhancing and redirecting T-cell activity within the tumor microenvironment. This strategy offers a promising avenue for developing targeted immunovirotherapy approaches for the treatment of solid tumors.
Authors
- Shahriyar Abdoli (ORCID: https://orcid.org/0000-0002-4052-332X)
- Ensieh Taheri
- Majid Shahbazi
Institutions
- Golestan University (IR)
- Golestan University of Medical Sciences (IR)
Publication Details
- Journal
- OncoTargets and Therapy
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/ott.s575869
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00