Depression Aggravates Immune‐Mediated Hepatitis Through <scp>NLRP3</scp> Overactivation Induced by Intestinal Microbiota
Depression aggravates immune-mediated hepatitis through disruption of intestinal barrier integrity and overactivation of hepatic NLRP3 inflammasome. Gut-derived L. formosensis could translocate to the liver and induce liver injury in mice. This study provides the necessity of screening for depression in patients with AIH.
Authors
- Hongyu Chu (ORCID: https://orcid.org/0009-0003-0544-388X)
- Liping Guo
- Nian Chen (ORCID: https://orcid.org/0000-0001-9804-5319)
- J. Liu
- Hui Yang
- Haifeng Liu
- Simin Zhou
- Ying Ran
- Lu Zhou
- Jiwen Li
- Man Liu
- Shijing Dong
- Xiaoyi Wang
- Yanni Li
- Xin Liu
- Jingwen Zhao
Institutions
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/cns.70743
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00