A Clinically Derived TCM Decoction (WD-3) Attenuates Malignant Phenotypes of Gastric Cancer through the PPARγ–AMPK Pathway
Using LC-MS, network pharmacology, docking, and in vitro/in vivo assays, we found that WD-3 suppresses GC cell proliferation/migration and xenograft growth, accompanied by increased total PPARγ and AMPK Thr172 phosphorylation, supporting involvement of the PPARγ/AMPK axis.
Authors
- Yuetong Xia
- Chunhui Jin
- Xiaodan Zhu (ORCID: https://orcid.org/0000-0003-2717-4396)
- Liang Ma (ORCID: https://orcid.org/0000-0003-4405-8119)
- C. C. Zhang
- Valeriy Smirnov
- Hengzhou Zhu
- Yuqing Geng
- Lei Huang
- Wenyue Zhao
- Jiejie Fan
- Jingyi Qian
- Yun Yuan
Institutions
- Nanjing University of Chinese Medicine (CN)
- Sechenov University (RU)
- Nantong University (CN)
- Yancheng First People's Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Wuxi Taihu Hospital (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Biological Procedures Online
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s12575-025-00320-2
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00