Complex I Modulator BI4500 Reduces MASH by Limiting Oxidative Stress and Reprogramming Lipid Metabolism via AMPK in MCD Rats
these findings indicate that Complex I modulation may represent a promising strategy to counteract MASLD progression toward MASH.
Authors
- Stefan G. Kauschke (ORCID: https://orcid.org/0009-0007-4524-8578)
- Laura Giuseppina Di Pasqua (ORCID: https://orcid.org/0000-0003-0103-1493)
- Andrea Ferrigno (ORCID: https://orcid.org/0000-0003-2337-2897)
- Peng Sun (ORCID: https://orcid.org/0000-0003-4424-5969)
- Michelangelo Trucchi
- Fausto Feletti
- Sofia Lotti (ORCID: https://orcid.org/0000-0001-9288-5683)
- M. Vairetti
- G. Palladini (ORCID: https://orcid.org/0000-0003-1312-7513)
- Anna Cleta Croce (ORCID: https://orcid.org/0000-0001-8996-2895)
- Francesca Protopapa
Institutions
- Boehringer Ingelheim (Germany) (DE)
- University of Pavia (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
Publication Details
- Journal
- Antioxidants
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3390/antiox15010082
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00