Real-world effectiveness and safety of eculizumab in AQP4-IgG-positive neuromyelitis optica spectrum disorder
Eculizumab demonstrated robust real-world effectiveness in reducing relapse rates and stabilizing disability, with an acceptable safety profile. Clinical outcomes may be influenced by attack phenotype, underscoring the importance of early intervention.
Authors
- Belgin Koçer (ORCID: https://orcid.org/0000-0003-2580-9650)
- Edgar Carnero-Contentti
- Serhan Sevim (ORCID: https://orcid.org/0000-0002-0518-3374)
- Sedat Şen (ORCID: https://orcid.org/0000-0001-6962-4960)
- Tuncay Gündüz (ORCID: https://orcid.org/0000-0003-4241-0908)
- Emine Koç (ORCID: https://orcid.org/0000-0003-4333-6797)
- Kadriye Ağan
- Güven Özkaya (ORCID: https://orcid.org/0000-0003-0297-846X)
- Vedat Çilingir (ORCID: https://orcid.org/0000-0003-4635-2880)
- Sanja Gluščević (ORCID: https://orcid.org/0000-0002-9230-9093)
- Valentina Camera (ORCID: https://orcid.org/0000-0002-4925-9000)
- Hüsnü Efendi (ORCID: https://orcid.org/0000-0002-9143-3893)
- Murat Kürtüncü (ORCID: https://orcid.org/0000-0003-3286-2652)
- Özden Kamışlı (ORCID: https://orcid.org/0000-0003-1114-7860)
- Uğur Uygunoğlu (ORCID: https://orcid.org/0000-0003-2866-4004)
- Cihat Uzunköprü (ORCID: https://orcid.org/0000-0002-9035-8537)
- Massimiliano Calabrese (ORCID: https://orcid.org/0000-0002-3362-7403)
- Caner Fevzi Demir
- Yeşim Beckmann (ORCID: https://orcid.org/0000-0001-5158-8834)
- Ipek Güngör-Doğan
- Burcu Altunrende
- Merve Bahar Ercan
- Haluk Gümüş
- Aksel Siva
- Cavit Boz
- Melih Tütüncü
- Gulsen Akman-Demir
- Mehmet Fatih Yetkin
- Sibel Canbaz-Kabay
- Damla Cetinkaya-Tezer
- Adriana Casallas-Vanegas
- Sena Destan Bunul
- Omer Faruk Turan
- Sami Omerhoca
- Furkan Saridas
- Serkan Demir
- Ayse Altıntas
- Nilufer Kale-Icen
- Basak Karakurum-Yuksel
- Nermin Tepe
- Murat Terzi
Institutions
- Balıkesir University (TR)
- Van Yüzüncü Yıl Üniversitesi (TR)
- University of Verona (IT)
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Koç University (TR)
- Selçuk University (TR)
- Universidad de La Sabana (CO)
- Karadeniz Technical University (TR)
- Başkent University (TR)
- Bursa Technical University (TR)
- Dokuz Eylül University (TR)
- Taksim German Hospital (TR)
- Ondokuz Mayıs University (TR)
- Izmir Kâtip Çelebi University (TR)
- Bezmiâlem Vakıf Üniversitesi (TR)
- Turkish Society of Hematology (TR)
- Istanbul University-Cerrahpaşa (TR)
- Instituto de Neurología Cognitiva (AR)
- Sağlık Bilimleri Üniversitesi (TR)
- Elazığ Eğitim ve Araştırma Hastanesi (TR)
- Mersin Üniversitesi (TR)
- Kocaeli Üniversitesi (TR)
- University of Montenegro (ME)
- Istanbul University (TR)
- Marmara University (TR)
- Erciyes University (TR)
- Gazi University (TR)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1007/s00415-025-13608-w
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00