NOTIFICATION: RhoGDIα Downregulates Androgen Receptor Signaling in Prostate Cancer Cells

NOTIFICATION: "RhoGDIα Downregulates Androgen Receptor Signaling in Prostate Cancer Cells," by Y. Zhu, C. Liu, R. Tummala, N. Nadiminty, W. Lou, and A. C. Gao, The Prostate 73, no. 15 (2013): 1614-1622, https://doi.org/10.1002/pros.22615. This Notification is for the above article, published online on 06 August 2013 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Dr. Samuel Denmeade; and Wiley Periodicals LLC. A third party reported that the cytoplasmic Pol II band and nuclear tubulin bands in Figure 4C had been duplicated. An investigation by the publisher also found that the RhoGDIα and Tubulin bands were duplicated between Figure 2D and Figure 2E. The authors responded to an inquiry by the publisher and reported that the authors used the same images in Figure 2D and 2E to show that RhoGDIa expression was knocked down by shGDI, as the same materials were used for Fig. 2E and 2D. The editors agreed with this statement and confirmed that the Pol II and tubulin bands in Figure 4C were intentionally marked with blank images and that the same blank image had been used to illustrate that Pol II and tubulin were used as loading controls for nuclear and cytoplasmic proteins, respectively. As such, the journal's investigation has determined that there are no concerns regarding the duplicated bands in Figures 2 and 4. This Notification has been agreed to in order to inform and alert readers of the investigation.