Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice
These findings highlight the HAergic system as a critical regulator of alcohol-related behaviors. The LHb HA signaling and norepinephrine neurotransmission might underlie pitolisant's potential novel therapeutic strategy for AUD.
Authors
- Yixin Fu
- Chao‐Yu Miao (ORCID: https://orcid.org/0000-0002-8176-3434)
- Yali Tang (ORCID: https://orcid.org/0000-0003-0115-6667)
- Bingqing Chen (ORCID: https://orcid.org/0009-0006-5357-1175)
- Tianhao Liu (ORCID: https://orcid.org/0000-0002-1991-5863)
- Yan Zhao (ORCID: https://orcid.org/0000-0003-0704-7410)
- Zhengzhong Yang
- J L Yang
- Duo Chen
- Xiaojiao Han
- Rao Fu
- Lipeng Zhou
- Jiang‐Hong Ye
- Zanhao Yang
Institutions
- Rutgers, The State University of New Jersey (US)
- Sun Yat-sen University (CN)
- Second Military Medical University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/cns.70732
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province