LncRNA H19 Promotes H <sub>2</sub> O <sub>2</sub> -Induced Human Trabecular Meshwork Cell Injury and Extracellular Matrix Production by Regulating the miR-20a-5p/Smad4 Axis

Long non-coding RNA H19 facilitates hydrogen peroxide-induced human trabecular meshwork cell injury and extracellular matrix deposition primarily by orchestrating the miR-20a-5p/Smad4 axis, with additional modulation of transforming growth factor-beta/Smad and nuclear factor erythroid 2-related factor 2 pathways.

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Publication Details

Journal
Current Eye Research
Published
2026-01-06
DOI
https://doi.org/10.1080/02713683.2025.2606332
Primary Topic
Cancer-related molecular mechanisms research
Type
article
Field-Weighted Citation Impact
0.00
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article

LncRNA H19 Promotes H 2 O 2 -Induced Human Trabecular Meshwork Cell Injury and Extracellular Matrix Production by Regulating the miR-20a-5p/Smad4 Axis

Xudong Li, Bin Wang
Current Eye Research
Cancer-related molecular mechanisms research
article

LncRNA H19 Promotes H 2 O 2 -Induced Human Trabecular Meshwork Cell Injury and Extracellular Matrix Production by Regulating the miR-20a-5p/Smad4 Axis

Xudong Li, Bin Wang
article en

Abstract

Long non-coding RNA H19 facilitates hydrogen peroxide-induced human trabecular meshwork cell injury and extracellular matrix deposition primarily by orchestrating the miR-20a-5p/Smad4 axis, with additional modulation of transforming growth factor-beta/Smad and nuclear factor erythroid 2-related factor 2 pathways.

Current Eye Research
Anyang Eye Hospital (CN)
Openalex Percentile: Top 95%
Cancer-related molecular mechanisms research
DOISourceOpenAlex
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LncRNA H19 Promotes H <sub>2</sub> O <sub>2</sub> -Induced Human Trabecular Meshwork Cell Injury and Extracellular Matrix Production by Regulating the miR-20a-5p/Smad4 Axis — Xudong Li, Bin Wang · Current Eye Research (2026) | TGRS Research Map | TGRS